Sf Giants Schedule 2025 Opening Day. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. The giants have some big roster holes entering the 2025 offseason.
San francisco giants opening day 2025! San francisco will open the season against the cincinnati reds on march 27 at great american ball park and will wrap up the 2025 campaign against the colorado rockies.